Identification of cis-regulatory elements from the C. elegans Hox gene lin-39 required for embryonic expression and for regulation by the transcription factors LIN-1, LIN-31 and LIN-39
نویسندگان
چکیده
منابع مشابه
Transcriptional upregulation of the C. elegans Hox gene lin-39 during vulval cell fate specification
Extracellular signaling pathways and transcriptional regulatory networks function during development to specify metazoan cell fates. During Caenorhabditis elegans vulval development, the specification of three vulval precursor cells (VPCs) requires the activity of Wnt, Notch, and Ras signaling pathways, and function of the Hox gene lin-39. LIN-39 protein levels are regulated in the VPCs by both...
متن کاملThe C. elegans hox gene lin-39 controls cell cycle progression during vulval development.
Cell fate specification during organogenesis is usually followed by a phase of cell proliferation to produce the required number of differentiated cells. The Caenorhabditis elegans vulva is an excellent model to study how cell fate specification and cell proliferation are coordinated. The six vulval precursor cells (VPCs) are born at the first larval stage, but they arrest in the G1 phase of th...
متن کاملThe Hox gene lin-39 is required during C. elegans vulval induction to select the outcome of Ras signaling.
The Ras signaling pathway specifies a variety of cell fates in many organisms. However, little is known about the genes that function downstream of the conserved signaling cassette, or what imparts the specificity necessary to cause Ras activation to trigger different responses in different tissues. In C. elegans, activation of the Ras pathway induces cells in the central body region to generat...
متن کاملInvestigation of lin-4 independent regulation of lin-28 in the C. elegans heterochronic
developmental timing pathway. (1) SPECIFIC AIMS Appropriate temporal patterning is essential for embryogenesis and post-embryonic development. Progression through the four larval stages in C. elegans is regulated by 'heterochronic' genes (reviewed in Slack and Ruvkun 1997; Ambros 2000). Heterochronic genes encode a diverse set of proteins, mutations in which result in the reiteration or omissio...
متن کاملThe C. elegans gene lin-36 acts cell autonomously in the lin-35 Rb pathway.
The Caenorhabditis elegans gene lin-36 acts to antagonize Ras-mediated vulval induction in a pathway that includes genes with products similar to the mammalian retinoblastoma (Rb) protein and the Rb-binding protein p48. We report that lin-36 encodes a novel protein of 962 amino acids. We demonstrate that lin-36 functions in and is expressed in the vulval precursor cells, establishing that the l...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2006
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2006.05.008